Derivatives of 6,7-dihydro-5h-imidazo[1,2-a]imidazole-3-carboxylic acid amides

• Main Authors: BARBOSA ANTONIO J.M, MILLER CRAIG ANDREW, BRUNETTE STEVEN RICHARD, HORAN JOSHUA COURTNEY, LEMIEUX RENE MARC, KOWALSKI JENNIFER A, LAWLOR MICHAEL DAVID, MCKIBBEN BRYAN
• Format: Patent
• Language: English
• Published: 28.02.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

595622 Disclosed herein are derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease. In one embodiment the derivative is (R)-5-(4-cy...