Derivatives of 6,7-dihydro-5h-imidazo[1,2-a]imidazole-3-carboxylic acid amides

595622 Disclosed herein are derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease. In one embodiment the derivative is (R)-5-(4-cy...

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Main Authors BARBOSA ANTONIO J.M, MILLER CRAIG ANDREW, BRUNETTE STEVEN RICHARD, HORAN JOSHUA COURTNEY, LEMIEUX RENE MARC, KOWALSKI JENNIFER A, LAWLOR MICHAEL DAVID, MCKIBBEN BRYAN
Format Patent
LanguageEnglish
Published 28.02.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:595622 Disclosed herein are derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease. In one embodiment the derivative is (R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid ((1S,2R)-1-{ 1-[5-(1,3-dimethyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-cyclopropylcarbamoyl} -2-hydroxy-propyl)-amide.
Bibliography:Application Number: NZ20100595622