INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS

594767 Disclosed herein is a compound of formula I, wherein the variables are defined in the specification, and the use thereof in the treatment of asthma. Specific embodiments of the compound include: [7-(4-benzyl-[1,2,3]triazol-1-yl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-acetic acid, { 7-[4-...

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Bibliographic Details
Main Authors COLUCCI, JOHN, VILLENEUVE, KARINE, BOYD, MICHAEL, BERTHELETTE, CARL, METHOT, JOEY
Format Patent
LanguageEnglish
Published 31.05.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:594767 Disclosed herein is a compound of formula I, wherein the variables are defined in the specification, and the use thereof in the treatment of asthma. Specific embodiments of the compound include: [7-(4-benzyl-[1,2,3]triazol-1-yl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-acetic acid, { 7-[4-(4-methoxy-phenyl)-[1,2,3]triazol-1-yl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl} -acetic acid, 4-[3-(10-carboxymethyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-7-yl)-3H-[1,2,3]triazol-4-yl]piperidine-1-carboxylic acid tert-butyl ester, and ((R)-7-{ 5-[1-(4-fluorophenyl)-1-hydroxyethyl]-[1,2,3]-triazol-1-yl} -6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-acetic acid.
Bibliography:Application Number: NZ20100594767