ENEMA PREPARATIONS AND THEIR USE

ABSTRACT - 593657 The disclosure relates to a liquid enema preparation suitable for administration intra-colonically which comprises a photosensitiser which is a 5-aminolevulinic acid (5-ALA) ester, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier o...

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Bibliographic Details
Main Authors GODAL, ASLAK, KLAVENESS, JO
Format Patent
LanguageEnglish
Published 26.07.2013
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:ABSTRACT - 593657 The disclosure relates to a liquid enema preparation suitable for administration intra-colonically which comprises a photosensitiser which is a 5-aminolevulinic acid (5-ALA) ester, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier or excipient and which further comprises: (a) one or more viscosity enhancing agents; and optionally one or more of the following: (b) one or more mucoadhesive agents or one or more mucolytic agents; (c) one or more penetration enhancers; and (d) one or more chelating agents; wherein the viscosity of the preparation increases after instillation into the area of interest. This enema preparation is suitable for the photodynamic treatment or diagnosis of cancer or non-cancerous conditions in the lower part of the gastrointestinal tract selected from inflammatory bowel disease, ulcerative colitis, Crohn's disease and irritable bowel syndrome
Bibliography:Application Number: NZ20090593657