PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK

• Main Authors: PENG, XIN, LIN, HONG, KASPAREC, JIRI, XIE, REN, JOHNSON, NEIL, W, ADAMS, JERRY, LEROY, FAITG, THOMAS, H, MELLINGER, MARK
• Format: Patent
• Language: English
• Published: 25.01.2013
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

592477 PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK The disclosure relates to a class of pyrazolylaminopyridines that inhibit Focal Adhesion Kinase (FAK), as well as compositions thereof. Compounds of the disclosure are useful in the treatment of proliferative diseases including, but not limited to cancer. The compounds of the disclosure are 2-[(5-Chloro-2-{ [3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino} -4-pyridinyl)amino]-N-(methyloxy)benzamide and 2-[(5-Chloro-2-{ [3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino} -4-pyridinyl)amino]-N-(methyloxy)benzamide, cancers for which the compounds of the disclosure may be used to treat are skin, breast, brain, cervical carcinomas, testicular carcinomas, astrocytic, colorectal, endometrial, esophageal, gastric, head and neck, hepatocellular, laryngeal, lung, oral, ovarian, prostate, thyroid carcinomas, sarcomas, lung, lymphomas, mesothelioma, Gastrointestinal, stomach, pancreas, small bowel, large bowel, kidney, bladder and urethra, liver, bone, Ewing's sarcoma, malignant lymphoma, multiple myeloma, malignant giant cell tumor chordoma, , brain, glioblastoma multiform, spinal cord, uterus, cervical, ovarian, squamous cell carcinoma, and hematologic cancers.