QUINUCLIDINE DERIVATIVES AS MUSCARINIC M3 RECEPTOR ANTAGONISTS

Disclosed is a 1-azonia-bicyclo[2.2.2]octane selected from the group consisting by way of example; (R)-1-[(6-Methyl-pyridin-3-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)5-1-azonia-bicyclo[2.2.2]octane X; (R)-1-[(6-Methyl-pyrazin-2-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonylox...

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Bibliographic Details
Main Authors METE, ANTONIO, FORD, RHONAN LEE, MATHER, ANDREW NIGEL, BULL, RICHARD JAMES, SKIDMORE, ELIZABETH ANNE
Format Patent
LanguageEnglish
Published 29.07.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed is a 1-azonia-bicyclo[2.2.2]octane selected from the group consisting by way of example; (R)-1-[(6-Methyl-pyridin-3-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)5-1-azonia-bicyclo[2.2.2]octane X; (R)-1-[(6-Methyl-pyrazin-2-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane X wherein X represents a pharmaceutically acceptable anion of a mono or polyvalent acid. Also disclosed is the use of said compounds in the treatment of chronic obstructive pulmonary disease, a method of preparation.
Bibliography:Application Number: NZ20080589091