Thiazole derivatives featuring an imidazolidine or triazole derivative as inhibitors of stearoyl-CoA desaturase

• Main Authors: HOU, DUANJIE, DALES, NATALIE, FU, JIANMIN, CHOWDHURY, SULTAN, KODUMURU, VISHNUMURTHY, FONAREV, JULIA, ZHANG, ZAIHUI, POKROVSKAIA, NATALIA, JIA, QI, SUN, SHAOYI
• Format: Patent
• Language: English
• Published: 27.07.2012
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Heterocyclic thiazole derivatives of formula (I) that modulate the activity of stearoyl-CoA desaturase (SCD) enzymes are disclosed, wherein the variables are as defined in the specification. These compounds are suitable for treating diseases related to elevated lipid levels, cardiovascular disease,...