Thiazole derivatives featuring an imidazolidine or triazole derivative as inhibitors of stearoyl-CoA desaturase

Heterocyclic thiazole derivatives of formula (I) that modulate the activity of stearoyl-CoA desaturase (SCD) enzymes are disclosed, wherein the variables are as defined in the specification. These compounds are suitable for treating diseases related to elevated lipid levels, cardiovascular disease,...

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Main Authors HOU, DUANJIE, DALES, NATALIE, FU, JIANMIN, CHOWDHURY, SULTAN, KODUMURU, VISHNUMURTHY, FONAREV, JULIA, ZHANG, ZAIHUI, POKROVSKAIA, NATALIA, JIA, QI, SUN, SHAOYI
Format Patent
LanguageEnglish
Published 27.07.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Heterocyclic thiazole derivatives of formula (I) that modulate the activity of stearoyl-CoA desaturase (SCD) enzymes are disclosed, wherein the variables are as defined in the specification. These compounds are suitable for treating diseases related to elevated lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome, dermatological disorders and the like.
Bibliography:Application Number: NZ20090587350