CONFORMATIONALLY RESTRICTED BIPHENYL DERIVATIVES FOR USE AS HEPATITIS C VIRUS INHIBITORS

Disclosed are biphenyl derivatives represented by general formula (I), or pharmaceutically acceptable salts thereof, wherein R2 and R2' form a five to eight membered unsaturated ring. An example of a compound included within the scope of the compound of formula (I) is methyl((1S)-1-(((2S)-2-(5-...

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Bibliographic Details
Main Authors DEON, DANIEL, H, BACHAND, CAROL, BELEMA, MAKONEN
Format Patent
LanguageEnglish
Published 27.04.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are biphenyl derivatives represented by general formula (I), or pharmaceutically acceptable salts thereof, wherein R2 and R2' form a five to eight membered unsaturated ring. An example of a compound included within the scope of the compound of formula (I) is methyl((1S)-1-(((2S)-2-(5-(9-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-6-methyl-6,7-dihydro-5H-dibenzo[c,e]azepin-3-yl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate. The compounds of formula (I) are used for treating HCV infections.
Bibliography:Application Number: NZ20090586990