4(-3-(-2-(PHENYL)MORPHOLINO)-2-OXOPYRROLIDIN-1-YL)-N-(THIAZOL-2-YL)BENZENESULFONAMIDE DERIVATI VES AND RELATED COMPOUNDS AS MODULATORS OF ION CHANNELS FOR THE TREATMENT OF PAIN

The disclosure relates to heterocyclic derivatives of formula (I) and pharmaceutically acceptable salts thereof that are useful as inhibitors of ion channels, which makes them suitable for the treatment of various type of pain., (I) or a pharmaceutically acceptable salt thereof, wherein, independent...

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Main Authors WHITNEY, TARA, MARTINBOROUGH, ESTHER, NEUBERT, TIMOTHY, ZIMMERMANN, NICOLE, STAMOS, DEAN, KAWATKAR, AARTI, SAMEER, NUMA, MEHDI, MICHEL DJAMEL
Format Patent
LanguageEnglish
Published 25.05.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The disclosure relates to heterocyclic derivatives of formula (I) and pharmaceutically acceptable salts thereof that are useful as inhibitors of ion channels, which makes them suitable for the treatment of various type of pain., (I) or a pharmaceutically acceptable salt thereof, wherein, independently for each occurrence: ring Z is a thiazole or thiadiazole optionally substituted with 0-2 occurrences of R; V is CH2, NH, O, or S; and R, R1, R2, and R3 are hydrogen, C1-C6 aliphatic, aryl, C3-C8 cycloaliphatic, halo, CN, NO2, CF3, OCF3, OH, NH2, NH(C1-C6 aliphatic), N(C1-C6 aliphatic)2, COOH, COO(C1 -C6 aliphatic), O(C1-C6 aliphatic), CHF2, or CH2F.
Bibliography:Application Number: NZ20080585332