MODULATORS OF NEURONAL REGENERATION

Disclosed is a method for identifying a PirB/LILRB antagonist comprising contacting a candidate agent with a complex comprising PirB/LILRB and myelin or a myelin-associated protein, or a functional fragment thereof, and detecting the ability of said candidate agent to inhibit the interaction between...

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Bibliographic Details
Main Authors ATWAL, JASVINDER, TESSIER-LAVIGNE, MARC
Format Patent
LanguageEnglish
Published 12.01.2012
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:Disclosed is a method for identifying a PirB/LILRB antagonist comprising contacting a candidate agent with a complex comprising PirB/LILRB and myelin or a myelin-associated protein, or a functional fragment thereof, and detecting the ability of said candidate agent to inhibit the interaction between PirB/LILRB and said myelin or myelin-associated protein, or fragment thereof, wherein the candidate agent is identified as an antagonist if the interaction is inhibited.
Bibliography:Application Number: NZ20070576272