N-methylaminomethyl isoindole compounds and compositions comprising and methods of using the same

Disclosed is a compound of formula (II) e.g. 3-(3,4-dichloro-phenyl)-1-[2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl-methyl-1-methyl-ureay or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein: * denotes chiral center; X is CH2 or C=O; R is alkyl; al...

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Bibliographic Details
Main Authors MULLER, GEORGE, W, CHEN, ROGER, S
Format Patent
LanguageEnglish
Published 22.12.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed is a compound of formula (II) e.g. 3-(3,4-dichloro-phenyl)-1-[2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl-methyl-1-methyl-ureay or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein: * denotes chiral center; X is CH2 or C=O; R is alkyl; alkoxy; amino; alkyl-amino; dialkylamino, for treating, managing or preventing a disease or disorder, wherein the disease or disorder is cancer, a disorder associated with angiogenesis, pain, macular degeneration or a related syndrome, a skin disease, a pulmonary disorder, an asbestos related disorder, a parasitic disease, an immunodeficiency disorder, a CNS disorder, CNS injury, atherosclerosis or a related disorder, dysfunctional sleep or a related disorder, hemoglobinopathy or a related disorder, or a TNF related disorder.
Bibliography:Application Number: NZ20070575689