Fused cyclic compounds as GPR40 receptor function modulators, for treating diabetes

Disclosed is a compound represented by the formula (I) e.g. [(3S)-6-({ 4'-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl} methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid, wherein R1 is R6-SO2- wherein R6 is a hydrocarbon group, hydroxy grou...

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Bibliographic Details
Main Authors YASUMA, TSUNEO, NEGORO, NOBUYUKI, ITOU, MASAHIRO, YAMASHITA, MASAYUKI
Format Patent
LanguageEnglish
Published 22.12.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed is a compound represented by the formula (I) e.g. [(3S)-6-({ 4'-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl} methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid, wherein R1 is R6-SO2- wherein R6 is a hydrocarbon group, hydroxy group, an amino group, a mercapto group, a cyano group, an optionally acyl group, or a halogen atom, or a 1,1-dioxidotetrahydrothiopyranyl group; X is a bond or a divalent hydrocarbon group; R2 and R3 are the same or different and each is a hydrogen atom, a halogen atom, a hydrocarbon group or a hydroxy group; R4 and R5 are the same or different and each is an alkyl group; ring A is a benzene; ring B is a 5- to 7-membered ring; Y is a bond or CH2; and R is a hydroxy group, or a salt thereof for the prophylaxis or treatment of diabetes.
Bibliography:Application Number: NZ20070574038