Aryl substituted sulfonic acid amides with medicinal effects due to interaction with the glucocorticoid receptor

Disclosed are compounds of formula I wherein X is a carbon or nitrogen atom, Ar is a phenyl or heteroaromatic ring and the remaining substituents are as defined in the specification, or a pharmaceutically suitable acid addition salt thereof, their interaction with glucocorticoid steroid receptors an...

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Main Authors GROVE, SIMON JAMES ANTHONY, OHLMEYER, MICHAEL, LITTLEWOOD, PETER THOMAS ALBERT, SHERBORNE, BRAD, KICZUN, MICHAEL JOHN, KINGSBURY, CELIA, HO, KOC-KAN, KULTGEN, STEVEN G, MORPHY, JOHN RICHARD, HAMILTON, NIALL MORTON, BROWN, ANGUS RICHARD
Format Patent
LanguageEnglish
Published 29.04.2011
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Disclosed are compounds of formula I wherein X is a carbon or nitrogen atom, Ar is a phenyl or heteroaromatic ring and the remaining substituents are as defined in the specification, or a pharmaceutically suitable acid addition salt thereof, their interaction with glucocorticoid steroid receptors and their use in treating stress related disorders, depression and anxiety.
Bibliography:Application Number: NZ20060569011