Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides

Disclosed is a reaction mixture comprising a compound comprising an aromatic ketone moiety, a compound comprising a hydroxylamine moiety, and an accelerant selecting from the group consisting of bifunctional aromatic amines, oxoamine derivatives, and compounds having a structure selected from group...

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Bibliographic Details
Main Authors TIAN, FENG, MIAO, ZHENWEI
Format Patent
LanguageEnglish
Published 30.09.2011
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Disclosed is a reaction mixture comprising a compound comprising an aromatic ketone moiety, a compound comprising a hydroxylamine moiety, and an accelerant selecting from the group consisting of bifunctional aromatic amines, oxoamine derivatives, and compounds having a structure selected from group I wherein Rx, Ry and Rz are selected from the group consisting of: Lx-H, Lx-alkyl, Lx-aryl, Lx-heteroaryl, Lx-alkenyl, Lx-alkynyl, Lx-alkoxy, and Lx-alkylamine, where Lx is a bond, C(=O), C(=NH), C(=NH)-NH, SO, and SO2. Further disclosed is a method for derivatizing an amino acid comprising contacting an amino acid in the presence of an accelerant as defined within the claims.
Bibliography:Application Number: NZ20060567234