Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides
Disclosed is a reaction mixture comprising a compound comprising an aromatic ketone moiety, a compound comprising a hydroxylamine moiety, and an accelerant selecting from the group consisting of bifunctional aromatic amines, oxoamine derivatives, and compounds having a structure selected from group...
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Main Authors | , |
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Format | Patent |
Language | English |
Published |
30.09.2011
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Subjects | |
Online Access | Get full text |
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Summary: | Disclosed is a reaction mixture comprising a compound comprising an aromatic ketone moiety, a compound comprising a hydroxylamine moiety, and an accelerant selecting from the group consisting of bifunctional aromatic amines, oxoamine derivatives, and compounds having a structure selected from group I wherein Rx, Ry and Rz are selected from the group consisting of: Lx-H, Lx-alkyl, Lx-aryl, Lx-heteroaryl, Lx-alkenyl, Lx-alkynyl, Lx-alkoxy, and Lx-alkylamine, where Lx is a bond, C(=O), C(=NH), C(=NH)-NH, SO, and SO2. Further disclosed is a method for derivatizing an amino acid comprising contacting an amino acid in the presence of an accelerant as defined within the claims. |
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Bibliography: | Application Number: NZ20060567234 |