Pyrimidine amide compounds as PGDS inhibitors

• Main Authors: MU, LAN, THURAIRATNAM, SUKANTHINI, MA, LIANG, MUNSON, HARRY RANDALL, ALDOUS, SUZANNE C, JIANG, JOHN ZIQI, SABOL, JEFFREY STEPHEN, LU, JINQI, VANDEUSEN, CHRISTOPHER LOREN
• Format: Patent
• Language: English
• Published: 31.03.2011
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed are pyrimidine amide compounds of formula (I) or hydrates, solvates, N-oxides or pharmaceutically salts thereof, wherein R1 is an aryl, heteroaryl or (C5-C6)-cycloalkyl and the rest of the substituents are disclosed within the specification. Also disclosed is the use of the said compound o...