An improved process for the preparation of beta-lactam antibiotic

Disclosed is a process for the preparation of highly pure sterile Meropenem trihydrate of the formula (I), which comprises the steps of: (a) dissolving the Meropenem or its hydrate salt in water in the presence of base and in the presence or absence of water-miscible organic solvents, (b) optionally...

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Main Authors SURULICHAMY, SENTHILKUMAR, GANPATHY, PANCHAPAKESAN, JANGALE, ARVIND ATMARAM, HENRY, SYRIL SUDHAN, SARANGDHAR, RAJENDRA JANARDAN, KALDATE, RAM DATTATRAY, SEKAR, SELVAKUMAR, DESHPANDE, PRAMOD NARAYAN, KARALE, SANJAY NIVRUTI
Format Patent
LanguageEnglish
Published 30.04.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed is a process for the preparation of highly pure sterile Meropenem trihydrate of the formula (I), which comprises the steps of: (a) dissolving the Meropenem or its hydrate salt in water in the presence of base and in the presence or absence of water-miscible organic solvents, (b) optionally filtering through micron filter, (c) adjusting the pH to 4.0 to 7.0, and (d) optionally adding solvent to yield the Meropenem trihydrate of formula (I).
Bibliography:Application Number: NZ20060566460