Xanthine derivatives as selective HM74A agonists

Disclosed is a xanthine derivative of formula (I), or a salt thereof, there R1 is -(alkylene)m-X-(alkylene)n-Y, X is heteroaryl or heterocyclyl, Y is aryl, heteroaryl, and O-aryl, and wherein the other variables and substituents are as defined in the specification. Also described is the use of the c...

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Bibliographic Details
Main Authors MASON, ANDREW MCMURTRIE, PINTO, IVAN LEO, HATLEY, RICHARD JONATHAN DANIEL
Format Patent
LanguageEnglish
Published 30.06.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed is a xanthine derivative of formula (I), or a salt thereof, there R1 is -(alkylene)m-X-(alkylene)n-Y, X is heteroaryl or heterocyclyl, Y is aryl, heteroaryl, and O-aryl, and wherein the other variables and substituents are as defined in the specification. Also described is the use of the compound to treat diabetic dyslipidaemia, mixed dyslipidaemia, hyperlipoproteinaemia, inflammatory diseases or conditions, heart failure, hypercholesteraemia, cardiovascular disease atherosclerosis, arteriosclerosis, hypertriglyceridaemia, type II diabetes mellitus, type I diabetes, insulin resistance, hyperlipidaemia, anorexia nervosa, obesity, coronary artery disease, thrombosis, angina, chronic renal failure, peripheral vascular disease or stroke.
Bibliography:Application Number: NZ20060565494