An improved process for the purification of perindopril

Disclosed is a process for the purification of perindopril, comprising: (i) treating perindopril with dicyclohexylamine in the presence of a solvent to form a salt of perindopril with dicyclohexylamine, (ii) isolating said dicyclohexylamine salt of a compound of formula (I), and (iii) treating the d...

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Main Authors DHAKE, VILAS NATHU, TAMBE, SUHAS GANPAT, RANANAWARE, UMESH BABANRAO, NEHATE, SAGAR PURUSHOTTAM, GODBOLE, HIMANSHU MADHAV, SINGH, GIRIJ PAL
Format Patent
LanguageEnglish
Published 30.10.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed is a process for the purification of perindopril, comprising: (i) treating perindopril with dicyclohexylamine in the presence of a solvent to form a salt of perindopril with dicyclohexylamine, (ii) isolating said dicyclohexylamine salt of a compound of formula (I), and (iii) treating the dicyclohexylamine salt of compound of formula (I) optionally in the presence of an organic solvent to form a salt with tert butyl amine, then, optionally, (iv) isolating compound of formula (I) with unknown impurities, and (v) converting to a dicyclohexylamine salt of compound of formula (I) with high purity. Also disclosed is another process for the purification of perindopril, comprising: (i) treating perindopril in a solvent with dicyclohexylamine to form a compound of formula (I) in the form of a salt with dicyclohexylamine, (ii) isolating said dicyclohexylamine salt of perindopril, (iii) treating perindopril in the form of a salt with dicyclohexylamine with an acidic agent to form perindopril free base, and (iv) isolating perindopril free base. Also disclosed is a dicyclohexylamine salt of perindopril.
Bibliography:Application Number: NZ20050561684