Pharmaceutical forms comprising vardenafil with improved pharmacokinetic properties

Disclosed is a drug formulation comprising vardenafil in the form of a salt with an acid or vardenafil with an acid, and sugar alcohols, which disintegrates rapidly in the mouth and is characterized in that at least 80% of the vardenafil dose in the substance form employed dissolves at 25°C in 10 ml...

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Bibliographic Details
Main Authors HEINIG, ROLAND, PAULI, KERSTIN, SERNO, PETER, HAYAUCHI, YUTAKA
Format Patent
LanguageEnglish
Published 24.12.2010
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Disclosed is a drug formulation comprising vardenafil in the form of a salt with an acid or vardenafil with an acid, and sugar alcohols, which disintegrates rapidly in the mouth and is characterized in that at least 80% of the vardenafil dose in the substance form employed dissolves at 25°C in 10 ml of physiological saline and the rate of release from the drug formulation in 900 ml of physiological saline within the first 5 minutes in the USP pedal stirrer apparatus at 50 rotations per minute at 37°C is at least 70%.
Bibliography:Application Number: NZ20060561004