Substituted aminoalkyl- and amidoalkyl-benzopyran derivatives

Disclosed are aminoalkyl- and amidoalkyl-benzopyran derivatives of formula (I) and the pharmaceutically acceptable salts thereof, wherein the variables are as defined in the specification. These compounds are active as selective and reversible monoamine oxidase type B (MAO-B) inhibitors in vitro and...

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Bibliographic Details
Main Authors THALER, FLORIAN, CAROTTI, ANGELO, CACCIA, CARLA, SALVATI, PATRICIA, MELLONI, PIERO, MAESTRONI, SARA
Format Patent
LanguageEnglish
Published 29.01.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are aminoalkyl- and amidoalkyl-benzopyran derivatives of formula (I) and the pharmaceutically acceptable salts thereof, wherein the variables are as defined in the specification. These compounds are active as selective and reversible monoamine oxidase type B (MAO-B) inhibitors in vitro and in vivo and are suitable for the prevention and treatment of CNS degenerative disorders including Parkinson's disease, Alzheimer's disease, restless leg syndrome, epilepsy, amylotrophic lateral sclerosis, stroke, attention deficit hyperactivity disorders, drug addiction, smoking cessation or obesity.
Bibliography:Application Number: NZ20060560666