Pyrazine derivatives for inhibiting RAF activity

Disclosed is an aminopyrazine derivative of formula (I), wherein W is -NRN4-, -O-, or -S-, RN4 is H or C1-4alkyl, Y is an optionally substituted carbocycle or heteroaryl, Z is optionally substituted phenyl, and wherein the optional substituents are as defined in the specification. Also disclosed by...

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Main Authors SPRINGER, CAROLINE JOY, GILL, ADRIAN LIAM, ROMAN VELA, ESTEBAN, TAYLOR, RICHARD DAVID, MARAIS, RICHARD MALCOLM, NICULESCU-DUVAZ, ION
Format Patent
LanguageEnglish
Published 24.12.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed is an aminopyrazine derivative of formula (I), wherein W is -NRN4-, -O-, or -S-, RN4 is H or C1-4alkyl, Y is an optionally substituted carbocycle or heteroaryl, Z is optionally substituted phenyl, and wherein the optional substituents are as defined in the specification. Also disclosed by the specification are pyrazine and pyridine derivatives of formula (II), wherein Q is N or CH, and wherein the other substituents are as defined in the specification. Also disclosed is the use of any of the above compounds for inhbiting RAF activity and for treating conditions ameliorated by the inhibition of RAF, such as cancer, melanoma, or malignant melanoma.
Bibliography:Application Number: NZ20050556125