Methods and compositions using immunomodulatory compounds for the treatment of immunodeficiency disorders
Compounds of formula (I) and (II), wherein the substituents are as defined in the specification, and the compounds 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione and 3-(4-amino-1-oxo-1,3 -dihydroisoindol-2-yl)-piperidine-2,6-dione are useful in the treatment of adenosine deaminase defici...
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Main Authors | , |
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Format | Patent |
Language | English |
Published |
24.12.2009
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Subjects | |
Online Access | Get full text |
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Summary: | Compounds of formula (I) and (II), wherein the substituents are as defined in the specification, and the compounds 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione and 3-(4-amino-1-oxo-1,3 -dihydroisoindol-2-yl)-piperidine-2,6-dione are useful in the treatment of adenosine deaminase deficiency, antibody deficiency with normal or elevated Igs, ataxia-tenlangiectasia, bare lymphocyte syndrome, common variable immunodeficiency, Ig deficiency with hyper-IgM, Ig heavy chain deletions, IgA deficiency, immunodeficiency with thymoma, reticular dysgenesis, Nezelof syndrome, selective IgG subclass deficiency, transient hypogammaglobulinemia of infancy, Wistcott-Aldrich syndrome, X-linked agammaglobulinemia, or X-linked severe combined immunodeficiency. |
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Bibliography: | Application Number: NZ20050555886 |