A pharmaceutical composition comprising a P2X7 receptor antagonist and a nonsteroidal anti-inflammatory drug

Disclosed is a combination of an adamantyl P2X7 receptor antagonist of formula (XI), wherein the substituents are as defined in the specification, and a selective inhibitor of COX-2 such as celecoxib, rofecoxib or valdecoxib. The combination is useful for the treatment of inflammatory disorders such...

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Bibliographic Details
Main Authors BOUGHTON-SMITH, NIGEL, CRUWYS, SIMON
Format Patent
LanguageEnglish
Published 25.09.2009
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed is a combination of an adamantyl P2X7 receptor antagonist of formula (XI), wherein the substituents are as defined in the specification, and a selective inhibitor of COX-2 such as celecoxib, rofecoxib or valdecoxib. The combination is useful for the treatment of inflammatory disorders such as rheumatoid arthritis and osteoarthritis.
Bibliography:Application Number: NZ20040545964