Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto

Disclosed are compounds of formula (I), wherein M and J are N, V is a bond, at least two of W, X and Y are N and the other is N or C optionally substituted; T, U and Z are C, T is optionally substituted, Q is O, S, S(O) or S(O)2, A and B are optionally substituted C1-3 alkylene, D is C or N substitu...

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Main Authors SAGE, CARLTON R, SHIN, YOUNG-JUN, XIONG, YIFENG, JONES, ROBERT M, SEMPLE, GRAEME, FIORAVANTI, BEATRIZ, REN, ALBERT S, CHOI, JIN SUN KAROLINE, CALDERON, IMELDA
Format Patent
LanguageEnglish
Published 31.07.2009
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are compounds of formula (I), wherein M and J are N, V is a bond, at least two of W, X and Y are N and the other is N or C optionally substituted; T, U and Z are C, T is optionally substituted, Q is O, S, S(O) or S(O)2, A and B are optionally substituted C1-3 alkylene, D is C or N substituted by R2, and the remaining substituents are as defined in the specification. The compounds are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as diabetes and obesity.
Bibliography:Application Number: NZ20040544200