Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics

Disclosed is an siRNA of apoptosis specific eukaryotic initiation factor 5A (eIF-5A) wherein said siRNA suppresses endogenous expression of apoptosis-specific eIF-5A in a cell and wherein the apoptosis specific eIF-5A is encoded by the nucleotide sequence of SEQ ID NO:30, SEQ ID NO:31, SEQ ID NO:32...

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Main Authors REZNIKOV, LEONID, CLICHE, DOMINIC, THOMPSON, JOHN E, TAYLOR, CATHERINE, GALTON, BRUCE C, DINARELLO, CHARLES, HOPKINS, MARIANNE, BOONE, ADRIENNE, POMERANTZ, BENJAMIN
Format Patent
LanguageEnglish
Published 30.04.2009
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Disclosed is an siRNA of apoptosis specific eukaryotic initiation factor 5A (eIF-5A) wherein said siRNA suppresses endogenous expression of apoptosis-specific eIF-5A in a cell and wherein the apoptosis specific eIF-5A is encoded by the nucleotide sequence of SEQ ID NO:30, SEQ ID NO:31, SEQ ID NO:32 or SEQ ID NO:33. The disclosed siRNA can be mixed with water and administered intranasally as a medicament.
Bibliography:Application Number: NZ20040544159