Isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A

• Main Authors: DANILOVSKI, ALEKSANDAR, CINCIC, DOMINIC, DUMIC, MILJENKO, ORESIC, MARINA, BUCAR, DEJAN-KRESIMIR, MESTROVIC, ERNEST, FILIC, DARKO, LAZARIC, KATICA, LAZAREVSKI, GORJANA, VINKOVIC, MLADEN, DUMBOVIC, ALOJZ, KNEZEVIC, ZDRAVKA
• Format: Patent
• Language: English
• Published: 30.11.2006
• Edition: 7
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

Disclosed is a substantially pure isostructural pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a- homoerythromycin A having the Formula (I), wherein: S is an organic solvent which is at least partially miscible with water and y is 0, and x is 1. Wherein the pseudopolymorph is characterized by the monoclinic space group P2 and average unit cell parameters comprising: Crystal axis lengths of: a = 15.5-17.O angstroms, b = 15.5-17.O angstroms and c = 17.5-19.5 angstroms; and Angles between the crystal axes of alpha = gamma = 90 degrees and beta = 106 degrees-112 degrees. The monohydrate forms of azithromycin claimed are useful for the treatment of bacterial and protozoan infections and inflammation-related diseases.