Isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A

Disclosed is a substantially pure isostructural pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a- homoerythromycin A having the Formula (I), wherein: S is an organic solvent which is at least partially miscible with water and y is 0, and x is 1. Wherein the pseudopolymorph is characterized by the mono...

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Main Authors DANILOVSKI, ALEKSANDAR, CINCIC, DOMINIC, DUMIC, MILJENKO, ORESIC, MARINA, BUCAR, DEJAN-KRESIMIR, MESTROVIC, ERNEST, FILIC, DARKO, LAZARIC, KATICA, LAZAREVSKI, GORJANA, VINKOVIC, MLADEN, DUMBOVIC, ALOJZ, KNEZEVIC, ZDRAVKA
Format Patent
LanguageEnglish
Published 30.11.2006
Edition7
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:Disclosed is a substantially pure isostructural pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a- homoerythromycin A having the Formula (I), wherein: S is an organic solvent which is at least partially miscible with water and y is 0, and x is 1. Wherein the pseudopolymorph is characterized by the monoclinic space group P2 and average unit cell parameters comprising: Crystal axis lengths of: a = 15.5-17.O angstroms, b = 15.5-17.O angstroms and c = 17.5-19.5 angstroms; and Angles between the crystal axes of alpha = gamma = 90 degrees and beta = 106 degrees-112 degrees. The monohydrate forms of azithromycin claimed are useful for the treatment of bacterial and protozoan infections and inflammation-related diseases.
Bibliography:Application Number: NZ20030535477