Sulfonylamino-derivatives as novel inhibitors of histone deacetylase

• Main Authors: BACKX, LEO JACOBUS JOZEF, PILATTE, ISABELLE NOELLE CONSTANCE, DE WINTER, HANS LOUIS JOS, VAN BRANDT, SVEN FRANCISCUS ANNA, VAN HEUSDEN, JIMMY ARNOLD VIVIANE, ANGIBAUD, PATRICK RENE, VERDONCK, MARC GUSTAAF CELINE, VAN EMELEN, KRISTOF
• Format: Patent
• Language: English
• Published: 28.04.2006
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Disclosed are compounds of formula (I), wherein: Each of Q, X. Y and Z is nitrogen or C, ring A is a optionally substituted carbocyclic or heterocyclic ring, and the remaining substituents are defined herein. The compounds are used for the manufacture of medicaments for treating proliferative diseases.