2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones to be used to treat neurodegenerative disorders, viruses and cancer
Substituted 2-aminopyridines of formula (I) are disclosed, wherein the variables are as defined in the specification. These compounds are potent inhibitors of cyclin-dependent kinases 4 (Cdk4) and are useful in treating disorders or conditions caused by abnormal cell proliferation, wherein the abnor...
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Main Authors | , , , , , , , |
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Format | Patent |
Language | English |
Published |
30.03.2007
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | Substituted 2-aminopyridines of formula (I) are disclosed, wherein the variables are as defined in the specification. These compounds are potent inhibitors of cyclin-dependent kinases 4 (Cdk4) and are useful in treating disorders or conditions caused by abnormal cell proliferation, wherein the abnormal cell proliferation is a cancer selected from the group consisting of cancers of the breast, ovary, cervix, prostate, testis, esophagus, stomach, skin, lung, bone, colon, pancreas, thyroid, biliary passages, buccal cavity and pharynx (oral), lip, tongue, mouth, pharynx, small intestine, colon-rectum, large intestine, rectum, brain and central nervous system, glioblastoma, neuroblastoma, keratoacanthoma, epidermoid carcinoma, large cell carcinoma, adenocarcinoma, adenocarcinoma, adenoma, adenocarcinoma, follicular carcinoma, undifferentiated carcinoma, papillary carcinoma, seminoma, melanoma, sarcoma, bladder carcinoma, liver carcinoma, kidney carcinoma, myeloid disorders, lymphoid disorders, Hodgkin's, hairy cells, and leukemia. |
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Bibliography: | Application Number: NZ20030534069 |