Use of PCR/STR multiplex analysis to detect chromosome aneuploidy

A method for the diagnosis of aneuploidy of a chromosome in a foetus is provided using the polymerase chain reaction (PCR). The method utilises a multiplex PCR assay comprising a plurality of chromosome-specific short tandem repeat (STR) markers. The method can be used to diagnose foetal trisomy and...

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Bibliographic Details
Main Authors LEVETT, LISA JULIA, LIDDLE, STUART
Format Patent
LanguageEnglish
Published 30.07.2004
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
COMPOSITIONS THEREOF
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
CULTURE MEDIA
ENZYMOLOGY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PHYSICS
PROCESSES OF PREPARING SUCH COMPOSITIONS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:A method for the diagnosis of aneuploidy of a chromosome in a foetus is provided using the polymerase chain reaction (PCR). The method utilises a multiplex PCR assay comprising a plurality of chromosome-specific short tandem repeat (STR) markers. The method can be used to diagnose foetal trisomy and monosomy responsible for disease conditions such as Downs Syndrome and Turner Syndrome, respectively. The method can also be used to diagnose the presence of other genetic conditions such as cystic fibrosis.
Bibliography:Application Number: NZ20020528085