Oxybenzamides derivatives as factor Xa inhibitors having antithrombotic effect

Compounds of the formula (I), their preparation processes, their use as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them are disclosed, R0-Q-X-Q'-W-U-V-G-M (I) wherein: R0 is aryl or heteroaryl; W is selected from aryl, heteroaryl, carbocyclic and heterocyc...

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Bibliographic Details
Main Authors WILL, DAVID WILLIAM, ZOLLER, GERHARD, MATTER, HANS, GERLACH, UWE, NAZARE, MARC, PEYMAN, ANUSCHIRWAN
Format Patent
LanguageEnglish
Published 26.11.2004
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of the formula (I), their preparation processes, their use as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them are disclosed, R0-Q-X-Q'-W-U-V-G-M (I) wherein: R0 is aryl or heteroaryl; W is selected from aryl, heteroaryl, carbocyclic and heterocyclic groups; and Q; X; Q', U, V, G and M area as defined in the specification. The compounds of the formula (I) exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended.
Bibliography:Application Number: NZ20010526615