Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis

Compounds of formula I (see below) are disclosed, where the formula variables are as defined in the disclosure. Compounds of formula I advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these com...

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Main Authors HUA, YE, HENDRICKSON, THOMAS F, JOHNSON, THEODORE O, CHAN, FORA P, CHU, SHAO SONG, SKALITZKY, DONALD JAMES, REICH, SIEGFRIED HEINZ, EASTMAN, BRIAN WALTER, YANG, YI, LUU, HIEP T
Format Patent
LanguageEnglish
Published 27.08.2004
Edition7
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Summary:Compounds of formula I (see below) are disclosed, where the formula variables are as defined in the disclosure. Compounds of formula I advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
Bibliography:Application Number: NZ20010523134