An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof

A purified antibody which specifically binds a TRAIL receptor DR5, wherein said antibody, has in vitro cell death-inducing activity in its soluble form at concentrations less than 1 ug/mL, in target cells expressing DR5, and in vivo tumorcidal activity in tumor cells expressing DR5, and wherein the...

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Bibliographic Details
Main Authors KIMBERLY, ROBERT P, ICHIKAWA, KIMIHISA, ZHOU, TONG, KOOPMAN, WILLIAM J
Format Patent
LanguageEnglish
Published 27.05.2005
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DERIVATIVES THEREOF
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
SUGARS
VINEGAR
WINE
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Summary:A purified antibody which specifically binds a TRAIL receptor DR5, wherein said antibody, has in vitro cell death-inducing activity in its soluble form at concentrations less than 1 ug/mL, in target cells expressing DR5, and in vivo tumorcidal activity in tumor cells expressing DR5, and wherein the antibody does not bind TRAIL receptor DR4, DcR1, or DcR2.
Bibliography:Application Number: NZ20010522881