Naphthyridine derivatives, processes for their preparation, their use and pharmaceutical compositions comprising them

Naphthyridine derivatives of the formula I, in which B, G, Z, X, Y, r, s and t have the meanings indicated in the claims. These compounds are vitronectin receptor antagonists and inhibitors of cell adhesion and are suitable for the therapy and prophylaxis of illnesses which are based on the interact...

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Main Authors GOURVEST, JEAN-FRANCOIS, GADEK, THOMAS R, SCHEUNEMANN, KARL-HEINZ, RUXER, JEAN-MARIE, PEYMAN, ANUSCHIRWAN
Format Patent
LanguageEnglish
Published 31.01.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Naphthyridine derivatives of the formula I, in which B, G, Z, X, Y, r, s and t have the meanings indicated in the claims. These compounds are vitronectin receptor antagonists and inhibitors of cell adhesion and are suitable for the therapy and prophylaxis of illnesses which are based on the interaction between vitronectin receptors and their ligands in cell-cell or cell-matrix interaction processes or which can be prevented, alleviated or cured by influencing such interactions. For example, they can be applied for inhibiting bone resorption by osteoclasts and thus for treating and preventing osteoporosis, or for inhibiting undesired angiogenesis or proliferation of cells of the vascular smooth musculature. Also described are processes for the preparation of compounds of the formula I, their use as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
Bibliography:Application Number: NZ20000516058