Method for the preparation of citalopram

A method for the preparation of citalopram comprising reaction of a compound 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran (formula IV) wherein R is halogen, or CF3-(CF2)n-SO2-O-; with a cyanide source in the presence of a palladium catalyst and a catalytic amount of Cu+...

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Bibliographic Details
Main Authors ROCK, MICHAEL HAROLD, SVANE, HENRIK, PETERSEN, HANS
Format Patent
LanguageEnglish
Published 30.01.2004
Edition7
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A method for the preparation of citalopram comprising reaction of a compound 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran (formula IV) wherein R is halogen, or CF3-(CF2)n-SO2-O-; with a cyanide source in the presence of a palladium catalyst and a catalytic amount of Cu+ or Zn2+, or with Zn(CN)2 in the presence of a palladium catalyst, and isolation of the corresponding 5-cyano compound (citalopram).
Bibliography:Application Number: NZ19990514979