Certain benzothiazine dioxide endothelin antagonists and processes for their preparation

A process for the preparation of benzothiazine dioxides of formula (I), which act as potent endothelin A antagonists with profound in vitro activity. The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction,...

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Main Authors REPINE, JOSEPH THOMAS, LEE, CHITASE, BUNKER, AMY MAE, EDMUNDS, JEREMY JOHN, CHENG, XUE-MIN, SKEEAN, RICHARD, DOHERTY, ANNETTE MARIAN, KANTER, GERALD DAVID
Format Patent
LanguageEnglish
Published 31.01.2003
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A process for the preparation of benzothiazine dioxides of formula (I), which act as potent endothelin A antagonists with profound in vitro activity. The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid haemorrhage.
Bibliography:Application Number: NZ19980502670