Method for treating pain and inflammation in dogs by administration of a COX-2 selective carprofen derivative

• Main Authors: LUNDY, KRISTIN MARIE, RICKETTS, ANTHONY PAUL
• Format: Patent
• Language: English
• Published: 26.04.2002
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A method of treating or preventing pain and inflammatory processes and diseases associated with the activity of inducible cyclo-oxygenase-2 (COX-2) in a member of the species Canis familiaris in need of such treatment, while at the same time reducing or eliminating undesirable side effects associated with simultaneous inhibition of the activity of constitutive cyclo-oxygenase-1 (COX-1) by selectively inhibiting COX-2 activity with reference to COX-1 activity, wherein the selectivity ratio of COX-2 : COX-1 activity inhibition is at least 3 : 1 based on ex vivo inhibition levels in whole blood measured at a dose giving ³80% COX-2 inhibition, comprising administering to the member of the species Canis familiaris an amount therapeutically effective for treating pain and inflammation in accordance with the above recited limitations, of an anti-inflammatory selective COX-2 inhibitory compound comprising a compound of the formula (I), wherein: R2 is (-C(X)(Y))n-C(=O)(A), where A is hydroxy, alkoxy, amino, hydroxyamino, monoalkylamino, dialkylamino; X and Y are independently H or alkyl; and n is 1 or 2; R6 is halogen, alkyl, trifluoromethyl, or nitro; R9 is H; alkyl; phenyl or phenylalkyl, where phenyl is optionally monosubstituted by fluoro or chloro; -C(=O)-R, where R is alkyl or phenyl, optionally mono-substituted by fluoro or chloro; or -C(=O)-O-R1, where R' is alkyl; where X and Y are different.