Pharmaceutical composition of an active compound in an ionic polymer increasing bioavailability of poorly soluble complexes

Stable water-insoluble complexes of poorly soluble compounds molecularly dispersed in water-insoluble ionic polymers are disclosed. Useful insoluble ionic polymers have a molecular weight greater than about 80,000 D and a glass transition temperature equal to or greater than about 50 DEG . The compo...

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Bibliographic Details
Main Authors SHAH, NAVNIT HARGOVINDAS, PHUAPRADIT, WANTANEE, SANDHU, HARPREET K, ALBANO, ANTONIO A
Format Patent
LanguageEnglish
Published 23.02.2001
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Stable water-insoluble complexes of poorly soluble compounds molecularly dispersed in water-insoluble ionic polymers are disclosed. Useful insoluble ionic polymers have a molecular weight greater than about 80,000 D and a glass transition temperature equal to or greater than about 50 DEG . The compounds are microprecipitated in the ionic polymers in amorphous form. The complexes according to the present invention significantly increase the bioavailability of poorly soluble therapeutically active compounds.
Bibliography:Application Number: NZ19990337884