Super oxide dismutase in liposome and it's use in therapy

• Main Authors: VORAUER-UHL, KAROLA, KATINGER, HERMANN, FURNSCHLIEF, ECKHARD
• Format: Patent
• Language: English
• Published: 25.05.2001
• Edition: 7
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

A cosmetic or pharmaceutical preparation for topical administration which comprises a low-fat or fat-free carrier together with a recombinant human Cu,Zn-SOD (rhSOD) in unilamellar liposomes. The liposomes have an average diameter of 200 nm or less and the rhSOD is present in a concentration of 0.01 to 5% by weight. The composition is capable of penetrating the tissue and treating pathological conditions that are caused by increased concentrations of superoxide radicals and/or the damage caused thereby. Such diseases include rheumatic joint inflammation, osteoarthritis, emphysema, bronchitis, ARDS and other similar diseases.