PHOSPHOLIPASE TOXIN FROM CORYNEBACTERIUM PSEUDOTUBERCULOSIS, RECOMBINANT PRODUCT AND VACCINE

Corynebacterium pseudotuberculosis phospholipase D (PLD) toxin in substantially pure form, and a method of preparation thereto from a crude toxin preparation. A vaccine composition comprising toxoided pure PLD toxin is used against caseous lymphadenitis in sheep. Nucleotide and amino acid sequences...

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Main Authors HAYNES, JILL ANNE, HODGSON, ADRIAN LESLIE MARK, COX, JOHN COOPER, BIRD, PHILLIP IAN, NISBET, IAN THOMAS, EGGLETON, DAVID GROSVENOR
Format Patent
LanguageEnglish
Published 28.04.1992
Edition5
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Corynebacterium pseudotuberculosis phospholipase D (PLD) toxin in substantially pure form, and a method of preparation thereto from a crude toxin preparation. A vaccine composition comprising toxoided pure PLD toxin is used against caseous lymphadenitis in sheep. Nucleotide and amino acid sequences of the toxin are disclosed, together with the cloning and expression of the PLD toxin gene in E. coli and coryneform bacteria.
Bibliography:Application Number: NZ19900233138