NEUROTROPHIC PEPTIDES, EXTRACTION FROM MAMMALIAN HIPPOCAMPAL TISSUE AND PHARMACEUTICAL COMPOSITIONS THEREOF

A novel neurotrophic peptide of sequence Ala-Ala-Asp-Ile-Ser-Gln-Trp-Ala-Gly-Pro-Leu which exhibits biological activity enhancing acetylcholine synthesis in cholinergic neurons is isolated and purified from a water soluble fraction of hippocampal tissue in mammals. A derivative of the peptide having...

Full description

Saved in:
Bibliographic Details
Main Authors KEIICHI ONO, KOSEI OJIKA, YOSHIHARU IKEDA, NOBUYUKI FUKUSHIMA, YASUYUKI UEKI, TSUNEMASA IRIE
Format Patent
LanguageEnglish
Published 25.02.1993
Edition5
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

Abstract A novel neurotrophic peptide of sequence Ala-Ala-Asp-Ile-Ser-Gln-Trp-Ala-Gly-Pro-Leu which exhibits biological activity enhancing acetylcholine synthesis in cholinergic neurons is isolated and purified from a water soluble fraction of hippocampal tissue in mammals. A derivative of the peptide having the same biological activity may be chemically synthesized using a conventional solid or liquid phase method. The peptide and derivative thereof are useful for the treatment of neurological degenerative disorders and dimentia.
AbstractList A novel neurotrophic peptide of sequence Ala-Ala-Asp-Ile-Ser-Gln-Trp-Ala-Gly-Pro-Leu which exhibits biological activity enhancing acetylcholine synthesis in cholinergic neurons is isolated and purified from a water soluble fraction of hippocampal tissue in mammals. A derivative of the peptide having the same biological activity may be chemically synthesized using a conventional solid or liquid phase method. The peptide and derivative thereof are useful for the treatment of neurological degenerative disorders and dimentia.
Author NOBUYUKI FUKUSHIMA
KEIICHI ONO
YOSHIHARU IKEDA
YASUYUKI UEKI
TSUNEMASA IRIE
KOSEI OJIKA
Author_xml – fullname: KEIICHI ONO
– fullname: KOSEI OJIKA
– fullname: YOSHIHARU IKEDA
– fullname: NOBUYUKI FUKUSHIMA
– fullname: YASUYUKI UEKI
– fullname: TSUNEMASA IRIE
BookMark eNqFjD0LwjAQQDPo4NdfkPsBCmoH5yO9koMmF5IUxKUUiYvSFur_RwV3pze8x1uqWT_0eaEejpogKYg3rMGTT1xS3AFdUkCdWBxUQSxYtBZrRgeGvReN1mMNiWNsCNCV4A0Gi5qaxPpjtFgvkb-DCMlQIKnWan7vnlPe_LhS24qSNvs8Dm2exu6W-_xq3fVUFIfzEYu_wRs6Rze7
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
Edition 5
ExternalDocumentID NZ233071A
GroupedDBID EVB
ID FETCH-epo_espacenet_NZ233071A3
IEDL.DBID EVB
IngestDate Fri Jul 19 15:30:03 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_NZ233071A3
Notes Application Number: NZ19900233071
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19930225&DB=EPODOC&CC=NZ&NR=233071A
ParticipantIDs epo_espacenet_NZ233071A
PublicationCentury 1900
PublicationDate 19930225
PublicationDateYYYYMMDD 1993-02-25
PublicationDate_xml – month: 02
  year: 1993
  text: 19930225
  day: 25
PublicationDecade 1990
PublicationYear 1993
RelatedCompanies SUMITOMO PHARMACEUTICALS CO LTD
MASAHIKO YAMAMOTO
KOSEI OJIKA
RelatedCompanies_xml – name: MASAHIKO YAMAMOTO
– name: SUMITOMO PHARMACEUTICALS CO LTD
– name: KOSEI OJIKA
Score 2.4273064
Snippet A novel neurotrophic peptide of sequence Ala-Ala-Asp-Ile-Ser-Gln-Trp-Ala-Gly-Pro-Leu which exhibits biological activity enhancing acetylcholine synthesis in...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title NEUROTROPHIC PEPTIDES, EXTRACTION FROM MAMMALIAN HIPPOCAMPAL TISSUE AND PHARMACEUTICAL COMPOSITIONS THEREOF
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19930225&DB=EPODOC&locale=&CC=NZ&NR=233071A
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV3dS8MwEA9zivqm8_tj5EH6ZHH9WreHIl2a0oppQ5vJ2MtouigidMNV_PdNu0592VtI4EgOLneX_O53ANwN7EyGoQZXs0zvq6ZpD1WuCUvtycRN778OzLymYyBRPxibTxNr0gJvm1qYmif0uyZHlBaVS3sv6_t6-feI5dXYytUDf5dTi0efOZ4yb8rFDOmSLMUbOZjGXowUhJxoqkSJo8u83dbcHbArY2i7wn7hl1FVkrL870_8I7BHpaiiPAYtUXTAAdq0XeuAfdL8dsthY3irE_ARVZA7lsQ0CBGkmLLQw-k9xBOWrHEg0E9iAolLSNUDOYKBzNhj5BLqPkMWpukYQzfyIA3chLgIj1lFhABRTGichnUtMWQBTnDsn4KujxkKVLnr2a9-ZtG0OZ1xBtrFohAXANo5H845t615LhMs0ctyyxS5sAzp87mmiUtwvkXI1daVa3C4hvvpqm7dgHb5-SVupUsuebdW5w-FlYns
link.rule.ids 230,309,783,888,25578,76884
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV3dS8MwEA9zivNN5_fHzIP0yeL6tW4PRbo0pdUlKW0mYy-j7aqI0A1X8d837Tr1ZW8hgSM5uNxdcr_fAXDXN2MRhmqJHMdqT9Z1cyAnSmbIXZG4qb3Xvp5WdAyE9ryx_jQxJg3wtsHCVDyh3xU5orCoVNh7Ud3Xy79HLKeqrVw9JO9iavHocsuR5jVcTBMuyZCcoYUD5jAkIWTRqURDSxV5u6nYO2BXxNf9kmQfvwxLSMryvz9xD8FeIETlxRFoZHkbtNCm7Vob7JP6t1sMa8NbHYMPWpbc8ZAFno9ggAPuOzi6h3jCw3UdCHRDRiCxCSl7IFPoiYydIZsE9ghyP4rGGNrUgYFnh8RGeMxLIgSIGAlY5FdYYsg9HGLmnoCOiznyZLHr2a9-ZnRan047Bc18kWfnAJppMpgniWnMU5FgZd04NfQszQxN-PxEUbILcLZFyOXWlVvQ8jgZzUY-fb4CB-vSP1VWjWvQLD6_shvhnoukU6n2ByWKjNw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=NEUROTROPHIC+PEPTIDES%2C+EXTRACTION+FROM+MAMMALIAN+HIPPOCAMPAL+TISSUE+AND+PHARMACEUTICAL+COMPOSITIONS+THEREOF&rft.inventor=KEIICHI+ONO&rft.inventor=KOSEI+OJIKA&rft.inventor=YOSHIHARU+IKEDA&rft.inventor=NOBUYUKI+FUKUSHIMA&rft.inventor=YASUYUKI+UEKI&rft.inventor=TSUNEMASA+IRIE&rft.date=1993-02-25&rft.externalDBID=A&rft.externalDocID=NZ233071A