NEUROTROPHIC PEPTIDES, EXTRACTION FROM MAMMALIAN HIPPOCAMPAL TISSUE AND PHARMACEUTICAL COMPOSITIONS THEREOF

A novel neurotrophic peptide of sequence Ala-Ala-Asp-Ile-Ser-Gln-Trp-Ala-Gly-Pro-Leu which exhibits biological activity enhancing acetylcholine synthesis in cholinergic neurons is isolated and purified from a water soluble fraction of hippocampal tissue in mammals. A derivative of the peptide having...

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Bibliographic Details
Main Authors KEIICHI ONO, KOSEI OJIKA, YOSHIHARU IKEDA, NOBUYUKI FUKUSHIMA, YASUYUKI UEKI, TSUNEMASA IRIE
Format Patent
LanguageEnglish
Published 25.02.1993
Edition5
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A novel neurotrophic peptide of sequence Ala-Ala-Asp-Ile-Ser-Gln-Trp-Ala-Gly-Pro-Leu which exhibits biological activity enhancing acetylcholine synthesis in cholinergic neurons is isolated and purified from a water soluble fraction of hippocampal tissue in mammals. A derivative of the peptide having the same biological activity may be chemically synthesized using a conventional solid or liquid phase method. The peptide and derivative thereof are useful for the treatment of neurological degenerative disorders and dimentia.
Bibliography:Application Number: NZ19900233071