PROLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS

Proline derivatives of the formulae:wherein R1 through R11 have defined values, and acid- and base-addition salts thereof, and equilibrium addition compounds of the aldehyde group thereof; processes for their preparation; pharmaceutical compositions; and intermediates for preparing said proline deri...

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Bibliographic Details
Main Authors STEIN, R.L, DUTTA, A.S, TRAINOR, D.A, WILDONGER, R.A
Format Patent
LanguageEnglish
Published 31.08.1987
Edition4
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Proline derivatives of the formulae:wherein R1 through R11 have defined values, and acid- and base-addition salts thereof, and equilibrium addition compounds of the aldehyde group thereof; processes for their preparation; pharmaceutical compositions; and intermediates for preparing said proline derivatives. The proline derivatives are human leukocyte elastase inhibitors which are useful, for example, in treating pulmonary emphysema.
Bibliography:Application Number: NZ19840207965