O-Acyl-4-fenyl-cykloheksanoler, deres salter, legemidler som inneholder disse forbindelser og deres anvendelse, samt fremgangsmåter for fremstilling av dem

PCT No. PCT/EP94/01276 Sec. 371 Date Jan. 17, 1997 Sec. 102(e) Date Jan. 17, 1997 PCT Filed Apr. 25, 1994 PCT Pub. No. WO95/29148 PCT Pub. Date Nov. 2, 1995This document describes O-acyl-4-phenyl-cycloalkanols of general formula I (I) wherein n denotes the number 0 or 1, m denotes the number 1 or 2,...

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Main Authors BUDZINSKI, RALPH-MICHAEL, HALLERMAYER, GERHARD, MAIER, ROLAND, EISELE, BERNHARD, MARK, MICHAEL, HURNAUS, RUDOLF, WOITUN, EBERHARD, MULLER, PETER
Format Patent
LanguageNorwegian
Published 24.10.1996
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
FODDER
FOODS OR FOODSTUFFS
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Summary:PCT No. PCT/EP94/01276 Sec. 371 Date Jan. 17, 1997 Sec. 102(e) Date Jan. 17, 1997 PCT Filed Apr. 25, 1994 PCT Pub. No. WO95/29148 PCT Pub. Date Nov. 2, 1995This document describes O-acyl-4-phenyl-cycloalkanols of general formula I (I) wherein n denotes the number 0 or 1, m denotes the number 1 or 2, p denotes the number 0 or 1, R1 and R2 each denote hydrogen, lower alkyl, alkenyl or alkynyl, which may optionally also be substituted, or together with the nitrogen atom between them denote 5- to 7-membered saturated, monocyclic, heterocyclic rings which may optionally also be interrupted by an oxygen or sulphur atom or by an imino group, R3, R4, R5 and R6 denote hydrogen or lower alkyl, R5 additionally denotes lower alkoxy, R7 denotes hydrogen, cycloalkyl, phenyl or substituted phenyl, naphthyl, tetrahydronaphthyl, thienyl, furyl or pyridyl and A denotes a chemical bond or alkyl, alkenyl or alkynyl having up to 17 carbon atoms, and also processes for preparing them, pharmaceutical compositions containing these compounds and the use of these pharmaceutical compositions which intervene in cholesterol biosynthesis. The antihypercholesterolaemic substances can be used for the treatment and prophylaxis of atherosclerosis; they inhibit the enzyme 2,3-epoxysqualene-lanosterol-cyclase.
Bibliography:Application Number: NO19960004525