Transdermalt terapeutisk system for administrering av physostigmin gjennom huden og en fremgangsmåte for fremstilling av systemet

• Main Authors: PROFITLICH, THOMAS, STANISLAUS, FRITZ, WALTER, KERSTEN, HILLE, THOMAS, DEURER, LOTHAR
• Format: Patent
• Language: Norwegian
• Published: 11.05.1995
• Edition: 6
• Subjects: ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; ADHESIVES; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; DYES; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; PAINTS; POLISHES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; USE OF MATERIALS AS ADHESIVES

PCT No. PCT/EP93/02970 Sec. 371 Date Jul. 12, 1995 Sec. 102(e) Date Jul. 12, 1995 PCT Filed Oct. 27, 1993 PCT Pub. No. WO94/10999 PCT Pub. Date May 26, 1994A transdermal therapeutic system for the administration of physostigmine to the skin, consisting of a backing layer impermeable to active substance, a pressure-sensitive reservoir layer containing 40 to 90%-wt. polymeric material and 0.1 to 20%-wt. physostigmine base or one of the pharmaceutically acceptable salts thereof, and of a detachable protective layer covering the reservoir layer, comprises in its reservoir layer acrylate- and/or methacrylate-based polymeric material and 0.1 to 40%-wt. of a softener containing the hydroxyl group with an HLB value between 1.1 and 12.0.