Antitussiv

• Main Authors: ENDOH, TAKASHI, UENO, SHINYA, KAWAI, KOJI, NEGISHI, YUJI, NAGASE, HIROSHI
• Format: Patent
• Language: Norwegian
• Published: 27.04.1995
• Edition: 6
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Det tilveiebringes nye antitussiver som er forskjellig fra eksisterende antitussiver eller dem som er under utvik- ling. Antitussiver inneholder morfinanderivater representert ved forbindelse 6: OH O Me eller farmakologisk akseptable syreaddisjonssalter derav og disses derivater eller salter som aktive bestanddeler. Antitussivene i henhold til foreliggende oppfinnelse har sterk antitussiv virkning som sterkt selektive K-opioid-ago- nister, og kan således benyttes som nyttige antitussiver. An antitussive containing a compound represented by general formula (I) or a salt thereof as the active ingredient, wherein symbol ... represents a double or single bond; R represents alkyl, cycloalkylalkyl, cycloalkenylalkyl, aryl, aralkyl, alkenyl, allyl, furan-2-ylalkyl or thiophene-2-ylalkyl; R represents hydrogen, hydroxy, nitro, alkanoyloxy, alkoxy, alkyl or -NR R , wherein R and R represents each hydrogen, etc.; R represents hydrogen, hydroxy, alkanoyloxy or alkoxy; A represents -XC(=Y)-, -XC(=Y)Z-, -X-, -XSO2- or -OC(OR )R -, wherein X, Y and Z represent each independently NR (wherein R represents hydrogen, etc.), S or O; B represents a valence bond, alkylene, etc., acyclic unsaturated hydrocarbon, etc.; R represents hydrogen, benzene ring, etc.; R and R represent each hydrogen, etc., or are combined together to represent -O-, -CH2-, -S-, etc.; and R represents hydrogen, alkyl or alkanoyl.