FREMGANGSMAATE FOR FREMSTILLING AV OXADIAZOLALKYLPURINDERIVATER

The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I and pharmaceutically acceptable salts thereof wherein A stands for C1-4 alkylene and R1 represents C1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C5-6 cycloalkyl or aminoalkyl of the Formula -(CH2)n-NR2R3 in wh...

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Bibliographic Details
Main Authors DEBRECZENI, LORAND, ANTUS, SANDOR, VIRAG, SANDOR, MARMAROSI, KATALIN, GOTTSEGEN, AGNES, MARTON, JENO, HEJA, GERGELY, KOVACS, GABOR, TARDOS, LASZLO, MINKER, EMIL, KORMOCZY, PETER, BOLEKOVSZKY, ANDREA, VARGAI, ZOLTAN, KORBONITS, DEZSO
Format Patent
LanguageNorwegian
Published 11.04.1988
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I and pharmaceutically acceptable salts thereof wherein A stands for C1-4 alkylene and R1 represents C1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C5-6 cycloalkyl or aminoalkyl of the Formula -(CH2)n-NR2R3 in which group n is an integer 1-3; R2 and R3 each stand for hydrogen or C1-4 alkyl or together with the adjacent nitrogen atom they are attached to form a 5- or 6-membered nitrogen containing heterocyclic ring which may optionally comprise a further nitrogen atom or an oxygen atom as heteroatom; or R1 stands for phenyl, hydroxyphenyl, carboxyphenyl, benzyl or dimethoxybenzyl The compounds of the Formula I can be prepared by methods known per se and can be used in therapy as antitussive agents.
Bibliography:Application Number: NO19870004216