FREMGANGSMAATE FOR FREMSTILLING AV 4(5)-ACETYL-2-METYLIMIDAZOL

Process for making 4(5)-acetyl-2-methylimidazole, a valuable intermediate, from 2-methylimidazole-4(5)-carboxaldehyde, the 1-position of which is protected by a benzyl group which may be unsubstituted or substituted. The process comprises a Grignard reaction followed by deblocking and oxidation, or...

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Bibliographic Details
Main Author CUE, BERKELEY WENDELL, JR
Format Patent
LanguageNorwegian
Published 04.06.1984
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Process for making 4(5)-acetyl-2-methylimidazole, a valuable intermediate, from 2-methylimidazole-4(5)-carboxaldehyde, the 1-position of which is protected by a benzyl group which may be unsubstituted or substituted. The process comprises a Grignard reaction followed by deblocking and oxidation, or by oxidation then deblocking. The oxidation is effected in a reaction-inert solvent with manganese dioxide.
Bibliography:Application Number: NO19830004398